The peculiarities of cytokine status in children suffering from persistent allergic rhinitis during early stages of allergenspecific immunotherapy

Background. To study dynamics of cytokine status during early stages of allergen-specific immunotherapy (ASIT) in children suffering from persistent allergic rhinitis (PAR).Methods. 30 children suffering from PAR have received complete course of ASIT. Serum levels ofILL-4, -5, -6, -8, -12, -13, sIL-2R were studied in 0, 7, 30 and 90 days and have been analyzed differentially in groups with good/excellent and incomplete effectiveness of treatment.Results. Good/excellent effectiveness of completed course of ASIT has been demonstrated in 17/30 (56,7%) children, partial effectiveness has been demonstrated for 13/30 (43,3%) ones.The decreased IL-12 and IL-6 levels and the increase of sIL-2R production were described for good/excellent results of treatment, but insufficient effectiveness was characterized by delayed dynamics of these cytokines. IL-8 level was increased in both groups but decreased effectiveness was associated with early start and long duration of it. IL-4 production was decreased in the good/ excellent group while on the second one changes of cytokine level were absent. IL-13 and IL-5 synthesis were increased in both groups.Conclusion. The effectiveness of ASIT in PAR patients depends on synthesis dynamics of ILL-4, -6, -8, -12, sIL-2R at the early treatment stages.