Open AccessASSOCIATION OF IL5, CCL26 AND CCL5 GENE POLYMORPHISMSWITH ATOPIC BRONCHIAL ASTHMA
Author(s) -
O. E. Voronko,
E. V. Dmitrieva-Zdorova,
Elena A. Latysheva,
М. Г. Аксенова,
Г. И. Сторожаков,
N. V. Bodoev
Publication year - 2010
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja875
Subject(s) - asthma , ccl5 , immunology , gene , single nucleotide polymorphism , allele , genotype , medicine , biology , genetics , t cell , immune system , il 2 receptor
The purpose of the work. In order to investigate whether single nucleotide polymorphisms С(-703)Т in IL5gene, T(+2497)G in CCL26 and A(-403)G in CCL5 gene contribute to atopic bronchial asthma developmentwe performed a comparative analysis of alleles and genotypes frequencies of these polymorphisms in Russianpatients from Moscow region.Materials and methods. DNA samples from 283 patients with atopic bronchial asthma and 227 healthy donorswere genotyped.Results. There were associations neither of С(-703)Т in IL5 gene, T(+2497)G in CCL26 and A(-403)G in CCL5gene with asthma nor with asthma severity.Conclusion. Therefore, we may conclude that genes responsible for activation and chemotaxis of eosinophils playan insignificant role in susceptibility to development of atopic bronchial asthma, and probably may influenceindirectly specific processes that occur in asthma.-