Open AccessThe level of immunoglobulin E in patients with pyoinflammatory diseases
Author(s) -
Т. А. Дружинина,
N U Alekseeva,
Б. А. Молотилов,
A S Ivachov,
A V Peskov
Publication year - 2009
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja872
Subject(s) - immunoglobulin e , medicine , atopy , immunology , appendicitis , antibody , allergy , gastroenterology , surgery
Object. Cause-and-effect relations^ assessment of immunoglobulin E leveTs increase in patients withpyoinplammatory diseases.Materials and methods. 80 patients with acute appendicitis, 51 patients with chronic recurrent furunculosis, 27patients with chronic osteomyelitis aged 16 to 60 years old have been examined. The patients with the increasedIgE level underwent clinical and allergologycal assessment. Patients with chronic pyoinplammatory diseaseshad been skin tested with the Staphylococcus aureus allergens.Results. Total IgE level was increased in all nosologic groups of patients. In patients with the increased IgE levelatopy or antihelminths antibodies have been established. In patients with chronic pyoinflammatory total IgElevel was not changed but negative correlative connections between the level of immunoglobulin and the latephase of immediate hypersensitivity reaction have been shown. Increased level of serum immunoglobulin E inpatients with acute appendicitis confirmed more serious involvement of appendix and surrounding tissues andthe higher indexes of white blood cells count before the operation.Conclusion. Increased IgE level in patients with pyoinflammatory diseases reflects Th2 type of immune responsemostly due to the condition of atopy or parasites. The higher rate of development of destructive and complicatedforms of appendicitis is typical for the patients with acute appendicitis and the increased IgE level.