Open AccessMultidrug resistance gene (MDR1) - marker of therapeutic resistance and severity of disease
Author(s) -
Ж. А. Миронова,
В. И. Трофимов,
Mariia A. Simakova,
Elena Iantchina,
М. В. Дубина
Publication year - 2009
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja867
Subject(s) - multiple drug resistance , p glycoprotein , gene , disease , pharmacodynamics , pharmacokinetics , biology , pharmacology , drug resistance , gene expression , medicine , genetics
Genes polymorphism is known to be one of the causes of the inadequate response to drugs or drugs resistance. In the most of cases drugs influence depends on interaction of several products of genes expression, which influence on drugs pharmacokinetics and pharmacodynamics.Present article concerns the review of publications and results of original investigations concerning the multidrug resistance gene (MDRl) expression associations with P-glycoprotein-170 (Pgp-170) expression in different diseases and the role of Pgp-170 in distribution of drugs in tissues.