Open AccessClinical and immunological phenotypes of the chronic rhinosinusitis with polyposis
Author(s) -
М А Мокроносова,
Ju S Ruyan,
D M Mustafaeva,
Е В Смольникова,
П. Г. Протасов
Publication year - 2009
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja859
Subject(s) - nasal polyps , immunoglobulin e , medicine , atopy , immunology , chronic rhinosinusitis , antibody , sinusitis , aspirin , allergy , incidence (geometry) , physics , optics
The pathogenesis of chronic rhinosinusitis with nasal polyposis is still unknown.The aim. To estimate IgE-antibodies to staphylococcal enterotoxines and fungal allergens mix in nasal polyps'supernatant and seraof three phenotypes of chronic rhinosinusitis.Patients and methods. Chronic rhinosinusitis with nasal polyposis with aspirin intolerance - 12 patients, chronic rhinosinusitiswith nasal polyposis with atopy - 15 patients, chronic rhinosinusitis with nasal polyposis without atopy and aspirin intolerance -10 patients, and 6 healthy persons were observed. The levels of ECP, tryptase, total IgE, IgE-antibodies to staphylococcal enterotoxines,fungal mix in sera and supernatant of polyp's tissue were detected by ImmunoCaplOO (Phadia AB).Results. The incidence of IgE-antibodies to staphylococcal enterotoxines makes up 12,6% in the sera of all patients, and 30% in polyp'stissue in nonatopic patients and in none of atopics. The local production of IgE-antibodies to fungi in polyp's tissue was high andrevealed in 30-73% of all patients (more often in patients with aspirin intolerance - in 73% of cases). There was no dependencebetween the incidence of IgE-antibodies to staphylococcal enterotoxines, fungal allergens mix in the sera and polyps and the chronicrhinosinusitis with nasal polyposis.Conclusion. The incidence of IgE-antibodies to staphylococcal enterotoxines, fungal allergens mix in polyp's tissue is higher than insera as in atopic as in nonatopic pts. There were IgE-antibodies to fungi in polyp's tissue in 73% of patients with aspirin intolerance. Thepresence of IgE-antibodies did not influence on the level of ECP and severity of chronic rhinosinusitis with nasal polyposis .