Open AccessAntimicrobial peptides is antimicrobial protection factors in atopic dermatitis and pyodermiapatients
Author(s) -
Е А Цывкина,
Е С Феденко,
Б В Пинегин
Publication year - 2009
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja858
Subject(s) - cathelicidin , antimicrobial peptides , atopic dermatitis , antimicrobial , beta defensin , innate immune system , microbiology and biotechnology , immunology , biology , staphylococcal skin infections , allergy , immune system , staphylococcus aureus , bacteria , skin infection , genetics
It is well known that atopic dermatitis patientsґ skin is highly contaminated with S. aureus. On the one handS. aureus can cause pyodermia, and on the other hand it is a classical allergen and can initiate IgE production.Also patientsґ skin is contaminated with some other bacteria, fungi and viruses. This predisposition to a skininfection arises, at least, partly, because of a defect in protection against the microbes, named innate immunity.One component of innate immune system are antimicrobial peptides: defensins and cathelicidin LL- 37. Humandefensins are peptides with cysteine structure, they are found out in circularly neutrophiles. Defensins are effectiveagainst a wide spectrum of microorganisms, including gram-negative, gram-positive bacteria, fungi and someviruses. Except their direct antimicrobial function, defensins have multiple roles as mediators of inflammation,have chemotactic, immunomodulating and cytotoxic activity and others as well. It is proved that the b-defensinsand cathelicidin LL- 37 level is decreased in atopic dermatitis patients and can predispose to microorganismscolonization on a skin of this patients. The level of antimicrobial peptides is increased in infected skin.