Open AccessCathelicidins - antimicrobal peptides and their role in immuno- pathology
Author(s) -
А С Будихина,
В V Pinegin
Publication year - 2009
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja857
Subject(s) - cathelicidin , innate immune system , antimicrobial peptides , inflammation , antimicrobial , acquired immune system , immunity , immune system , immunology , lipopolysaccharide , biology , microbiology and biotechnology
Cathelicidins are a family of cationic amphipathic antimicrobial polypeptides, which play an important role in innate and adaptive immunity. The knowledge of biological effects of these peptides allows to use them not only as an alternative to common antimicrobial therapies. Cathelicidins may also be used for the re-activation of an immune system that has been suppressed by an infection or inflammation, for modulation of inflammation as lipopolysaccharide-binding drugs, and for the activation of regenerative processes. Besides, examination of cathelicidins may serve to detect individuals prone to infectious diseases, to monitor infectious process control in these patients, and to select efficient therapy.