Open AccessThe cytokine status in infants with atopic dermatitis
Author(s) -
Т. Б. Сенцова,
С Н Денисова,
M Yu Belitskaya,
Т. Б. Сенцова,
С Н Денисова,
M Yu Belitskaya
Publication year - 2011
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja793
Subject(s) - immunoglobulin e , immunology , atopic dermatitis , immune system , humoral immunity , medicine , cytokine , allergen , allergy , antibody
Background. To estimate the process of immunoregulation in infants aged 0-36 months with atopic dermatitis (AD) we have examined serum levels of cytokines and selectines in 89 infants with AD of different severity. Materials and methods. The serum concentration of total IgE was determined by the ELISA immunoenzyme method. For quantitative determination of the allergen-specific IgE and IgG to cow milk protein the non-concurrent immunoenzyme analysis was used. The serum levels of IFN-γ, IL-2, IL-4, IL-5, IL-12, IL-13 was determined by the ELISA - enzym-linked immunosorbent assay.Results of this study showed the role of cellular immunity in the development of allergic inflammation and humoral specific response with significant role of the local immune response, in ADinfants with predominantly IgE response/ In patients with mixed type of immune response (IgE+IgG) we revealed increased serum concentration of IL-4, IL-5, IL-12 and IL-13 compared with control group. We revealed high levels of leukocyte migration factors: ICAM-1 (p