Open AccessNEUTROPHILS AND RESPIRATORY TRACT BACTERIAL INFECTIONS IN PATIENTS WITH BRONCHIAL ASTHMA AND COPD
Author(s) -
Г Б Федосеев,
Basil I Trofimov,
N N Rogacheva,
T S Razumovskaya,
Г Б Федосеев,
В. И. Трофимов,
N S Razumovskaya
Publication year - 2011
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja785
Subject(s) - asthma , copd , medicine , respiratory tract , sputum , respiratory system , respiratory tract infections , immunology , pulmonary disease , pathology , tuberculosis
The article concerns the role of respiratory tract bacterial infections in development of bronchial asthma and COPD. Analysis is based on current publications and results of clinical investigations. Ability of neutrophils to protect the respiratory system from bacterial agents is underlined. The results obtained during investigation of 132 bronchial asthma and 33 COPD patients showed that in allergic asthma patients high percentage of sputum neutrophils is associated with normal FEV1% and mild course of the disease. In COPD patients high percentage of sputum neutrophils is usually associated with low FEV1%. It is proposed, that in these patients functional activity of neutrophils is associated with predominant injury of respiratory structures.