Open AccessThe estimation of efficiency of diet therapy in atopic dermatitis and food allergy in children
Author(s) -
V A Revyakina,
К. Г. Шарапова,
E. Yu Berezina,
Т Б Сенцова,
O Yu Monosova,
A M Zotova
Publication year - 2012
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja737
Subject(s) - hypoallergenic , atopic dermatitis , medicine , elimination diet , milk allergy , immunoglobulin e , food allergy , erythema , itching , allergy , rash , antibody , immunology , allergen
Background. Clinical and immunological estimation of efficiency of different special formulas in children with atopic dermatitis due to food allergy. Methods. Fifty four children with atopic dermatitis aged 0,5—3 years old were examined. Children were divided into three groups on the base of their diet therapy. The 1st group included 15 patients on the hypoallergenic milk-free diet, the 2nd group (18 patients) was fed by goat milk formula, and the 3rd group (21 children) was fed by special formula with high hydrolyzed protein. The dynamics of serum levels of IgE and IgG antibodies to cow milk protein and its fractions, and dynamics of cytokine levels (IL-4, IL-5, and IL-10) were measured during different types of diet therapy. Results. The positive skin changes during diet therapy included decrease of erythema, exudation and itching, gradual regression of rash. In 3 months of therapy complete clinical remission was achieved in 10 (66,7%) children in the 1st group, in 14 (77,8%) children in the 2nd group and in 15 (71,7%) children in the 3rd group. The significant decrease of levels of IgG antibodies levels to cow milk protein and its fractions in children during different elimination diets was determined. The significant decrease of levels of specific IgE antibodies to cow milk protein (p