Open AccessCLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF RECURRENT OBSTRUCTIVE BRONCHITIS IN CHILDREN
Author(s) -
Марина Георгиевна Лукашевич,
Марина Георгиевна Лукашевич,
Л. П. Сизякина,
Л. П. Сизякина,
А. А. Сависько,
А. А. Сависько
Publication year - 2012
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja698
Subject(s) - medicine , bronchitis , pediatrics , respiratory tract , rehabilitation , age groups , respiratory system , physical therapy , demography , sociology
Background. The aim of the study is to evaluate immunopathogenic mechanisms of lower respiratory tract reobstructions and to develop diagnostic, treatment and prophylaxis mechanisms of this syndrome and transformation to BA. Methods. 78 children with repeated episodes of obstructive bronchitis (OB) and 30 conditionally healthy children, formed a control group, were examined. Both groups of children were divided into two age groups — under 3 years old and older than 3 years old. All the patients underwent immunological examination. Results. The longer and heavier course of OB episodes, accompanied by the disturbance of ripening and, in less degree, differentiation of T-lymphocyte subpopulation, decreasing of readiness for apoptosis were revealed in 3 years old patients. In the age group older than 3 years old the OB episodes were taking their course easier, started at the earlier age, repeated more often, were accompanied by decreasing of CD4+-lymphocytes, decreasing of early activation processes, intensification of late activation processes. Conclusion. The revealed peculiarities testify to heterogeneity of children groups with repeated OB episodes and make working out individual rehabilitation programs necessary.