Open AccessChronic idiopathic urticaria. The diagnostic problem
Author(s) -
Р Н Голубчикова,
И В Данилычева
Publication year - 2012
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja672
Subject(s) - medicine , immunology , anti thyroid autoantibodies , autoantibody , anti nuclear antibody , serology , serum protein electrophoresis , angioedema , anamnesis , chronic urticaria , thyroglobulin , cryoglobulins , etiology , erythrocyte sedimentation rate , antibody , immunoglobulin e , dermatology , monoclonal , monoclonal antibody
The causes of chronic urticaria are not revealed in 80—95% of cases. The most important part of the investigation is an anamnesis morbi. Specific laboratory tests should be selected on the basis of diagnostic hypothesis. Tests may include: full blood count, erythrocyte sedimentation rate, C-reactive protein, routine biochemistry, glucose, thyroid function, thyroid autoantibodies, antinuclear antibodies, immunoglobulins, protein electrophoresis, complement C3 and C4 components, cryoglobulins, allergen-specific IgE, serology for infections, stool samples for parasites and urine analysis. Al least 30% of patients with chronic idiopathic urticaria appear to have an autoimmune aetiology. Although a positive serum skin test has a reasonable specificity to establish the autoimmune nature of urticaria, a negative result has high negative predictive value.