Open AccessImmunological and allergological aspects of macrolides application in clinic
Author(s) -
И П Балмасова,
И П Балмасова,
О. Ф. Еремина,
О. Ф. Еремина,
M M Gultyaev,
М М Гультяев,
О В Попова,
О В Попова,
И П Балмасова,
О. Ф. Еремина,
M M Gultyaev,
О В Попова
Publication year - 2007
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja64
Subject(s) - respiratory tract , proinflammatory cytokine , mucus , antimicrobial , immunology , eosinophil , medicine , respiratory system , microbiology and biotechnology , asthma , biology , inflammation , ecology
The review analyzes clinical significance of immunotropic properties of macrolides. Macrolides have effect of phagocytic activity and cell motility, inhibit production of proinflammatory cytokines, increase antimicrobial function of mucosa epithelium. They significantly decrease the intensity of inflammatory reactions in local and systemic infectious processes, especially in respiratory tract pathology including that of allergic genesis. Efficacy of macrolides in bronchial asthma is extended by suppressing eosinophil functioning, antispastic effect of these preparations over smooth muscles and decreasing of mucus formation in bronchi.