Open AccessEFFICIENCY OF ALLERGENSPECIFIC IMMUNOTHERAPY IN ADOLESCENTS WITH POLLINOSIS
Author(s) -
И.И. Балаболкин,
И.И. Балаболкин,
E V Beljaeva,
Е. В. Беляева,
О. Б. Соснина,
О. Б. Соснина,
Л. Д. Ксензова,
Л. Д. Ксензова,
И А Ларькова,
И А Ларькова
Publication year - 2013
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja621
Subject(s) - immunoglobulin e , medicine , immunology , allergy , antibody
. Efficiency of ASIT in adolescents with pollinosis is not enough investigated. Materials and methods. Authors investigated 45 adolescents with pollinosis of 10—17 years old. Investigation included skin tests with atopic allergens, determine of total IgE, (ELISE, Russia), specific IgE (MAST, USA), sIL2R, IL4, IL5, IL8, IL10, IL13, IFNγ (ELISE, Belgium) in blood serum. Rush subcutaneous ASIT with pollen allergens was performed. Results. ASIT proved to be effective in 39 (86,4%) adolescents with pollinosis. In 52% adolescents with pollinosis and food allergy to products of plant origin was noticed increasing of tolerance to them. Normalization of levels of IL5 and IL 10 in blood serum was noticed. ASIT was more efficient in children with moderate increasing of IgE levels in blood serum. Conclusion. ASIT is effective method of treatment of adolescents with pollinosis.