Open AccessPHENOTYPES AND ENDOTYPES OF BRONCHIAL ASTHMA: FROM PATHOGENESIS AND CLINICAL FEATURES TO THERAPY
Author(s) -
О М Курбачева,
О М Курбачева,
К С Павлова,
К С Павлова
Publication year - 2013
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja596
Subject(s) - asthma , medicine , disease , etiology , intensive care medicine , phenotype , pathogenesis , clinical phenotype , immunology , bioinformatics , pathology , biology , genetics , gene
Questions of bronchial asthma heterogeneity, approaches to allocation of various phenotypes on the basis of clinical signs, biological and genetic markers and endotypes taking into account an etiology and pathophysiology of the disease are considered in the article. Allocation of phenotypes / endotypes promote the best understanding of essence of a disease and it is expedient for development of an individual approach to therapy as some options of a current OH can differ the resistant answer to standard treatment.