Open AccessREVIEW OF THE ROLE OF PERIOSTIN AS A NOVEL BIOMARKER OF BRONCHIAL ASTHMA
Author(s) -
S S Masalskiy,
A S Kalmikova,
О П Уханова,
Leonid Klimov,
A V Razgulaeva
Publication year - 2014
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja480
Subject(s) - periostin , asthma , exhaled nitric oxide , pathogenesis , biomarker , medicine , eosinophilia , immunology , inflammation , extracellular matrix , biology , bronchoconstriction , biochemistry , microbiology and biotechnology
The survey shows the role of periostin in the asthma research. This is extracellular protein involved in the pathogenesis of chronic inflammation in asthma in children and adults. The role of periostin in the pathogenesis of atopic and nonatopic diseases was analyzed in this review. The appearance of the biomarker, responsible for airways remodeling, can give a clear understanding of the clinical stage of the process and the ability to achieve asthma control. Correlation between periostin, peripheral blood eosinophilia and fractional exhaled nitric oxide can be considered as an additional criterion for control of the disease.