Open AccessOropharyngeal microbiota features in patients with bronchial asthma, depending on the severity of the disease and the level of control
Author(s) -
С. В. Федосенко,
Л. М. Огородова,
Anna Popenko,
В. А. Петров,
A V Tyacht,
Irina V. Saltykova,
И. А. Деев,
Evgeny Kulikov,
Н. А. Кириллова,
Vadim Govorun,
Elena Kostryukova
Publication year - 2015
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja450
Subject(s) - asthma , medicine , disease , throat , antibiotics , biology , microbiology and biotechnology , surgery
This paper presents the results of the comparative analysis of the taxonomic composition of oropharyngeal microbiota obtained by swab from the back of the throat of the 2 groups of patients with bronchial asthma: patients with mild persistent controlled or partially controlled asthma, and patients with severe uncontrolled asthma. The swab collecting procedure was performed in a stable period of the disease without exacerbations episodes and systemic antibiotic therapy courses within the previous 4 weeks or more. Taxonomic identification of the microbiota was performed using conserved regions of bacterial 16S rRNA sequencing. The study revealed a number of differences in the representation of the identified microorganisms that make up the oropharyngeal microbiota in patients with asthma, depending on the severity of asthma, the level of control, other clinical and anamnestic features.