Open AccessMarkers of endothelial dysfunction in bronchial asthma patients
Author(s) -
N M De Silva,
V I Nemtsov,
В. И. Трофимов
Publication year - 2015
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja438
Subject(s) - asthma , medicine , homocysteine , endothelial dysfunction , spirometry , gastroenterology , endothelin 1 , pulmonary function testing , cardiology , receptor
Objective. To identify endothelial dysfunction (ED) in patients with bronchial asthma (BA) in the acute phase, to establish the relationship between levels of homocysteine (HC) and endothelin-1 (ET-1) in the blood, and the causes of the disease. Materials and methods. 32 young patients in acute phases of bronchial asthma divided into three groups depending on the cause of bronchial asthma, and 10 healthy individuals were included in the study. Respiratory function assessed by spirometry with bronchodilatation test, serum endothelin-1 level was determined with immunofermental analysis, homocysteine level was determined with plasma liquid chromatography method. The results. There was a significant statistical difference between groups in terms of homocysteine, endothelin-1 levels in blood. Significant positive correlation between the levels of homocysteine and endothelin-1 in patients with allergic bronchial asthma and a significant negative correlation between the marker levels of endothelial dysfunction and lung function were identified. Conclusion. Acute phase of asthma accompanied by endothelial dysfunction, characterized by different levels of homocysteine and endothelin-1 in blood, depending on the genesis of the disease.