Open AccessEpidermal barrier defect in atopic dermatitis children and its role in the development of allergic sensitization and respiratory allergy
Author(s) -
Н.Б. Мигачева,
А. В. Жестков,
Т. И. Каганова,
O G Elisutina,
Г И Бибарсова,
О В Штырбул
Publication year - 2015
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja436
Subject(s) - atopic dermatitis , sensitization , medicine , allergy , dermatology , transepidermal water loss , skin barrier , atopy , respiratory allergy , asthma , immunology , respiratory system , allergen , pathology , stratum corneum
Atopic dermatitis (AD) is the most common allergic disease in young children which is often (almost in half of cases) the beginning of so-called «allergic march», followed by the addition of respiratory allergy symptoms. In this review we present some studies to explain one of the possible mechanisms for the realization of allergic march associated with transepidermal sensitization in atopic dermatitis infants. Perhaps, the data may help in establishment of new strategies for allergy prevention in the near future.