Open AccessImmunologic reactivity and metabolic activity of blood lymphocytes associated with pathogenic form of allergic rhinosinusitis
Author(s) -
О. А. Коленчукова,
С. В. Смирнова,
Anastasiia Lapteva
Publication year - 2015
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja422
Subject(s) - immunology , anaerobic exercise , medicine , catabolism , immune system , secretion , metabolism , physiology
We had studied functional and metabolic activity of blood lymphocytes in allergic rhinosinusitis (ARS) - atopic ARS and polypous rhinosinusitis (PRS). ARS is characterized by the increased level of CD25+ and HLA-DR+-lymphocytes in peripheral blood, IgA concentration in blood serum and sIgA in nasal secretion. At the same time the deviation of immune response is directed towards Th2-lymphocytes and is accompanied by high content of IL-4 and IL-6 in blood serum and nasal secretion. The activity of metabolic enzymes in blood lymphocytes in ARS is caused by exasperation of plastic processes, intensification of lipoid catabolism and increase of the speed of both anaerobic and aerobic oxidation. There are the following specific features of PRS: high level of CD19+-cells, activation of Thl-lymphocytes and high level of those cytokines, which they produce (IFN-γ and IL-2 in blood serum and nasal secretion). At the same time intensification of aerobic enzymes and lipoid metabolism and decreasing of anaerobic processes and aminoacid metabolism in blood lymphocytes are in the progress.