Open AccessThe compensatory reactions of the immune system in patients with a defect of antibodies synthesis - agammaglobulinemia
Author(s) -
L. P. Sizyakinа,
И. И. Андреева
Publication year - 2016
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja359
Subject(s) - immune system , immunology , antibody , innate immune system , humoral immunity , innate lymphoid cell , effector , acquired immune system , biology , peripheral blood , foxp3 , immunity , cellular immunity , microbiology and biotechnology
In the present study, we describe changes in the immune state of patients with X-linked agammaglobulinemia (X-AGG). We observed the dynamic of the cellular component of the immune system of adaptive and cellular and humoral components of the innate immunity. We investigated parameters of the maturation, differentiation, activation of T-lymphocytes, NK-cells, monocytes, cytokines, antimicrobial peptides in the peripheral blood of these patients. We found the compensatory activation of the effectors systems. We observed decrease of CD4+Foxp3+cells, elevation of the activation functions of T-cells. Microbicidial activity of neutrophils was decreased.