Open AccessAGE-RELATED PATHOGENTIC SPECIFICITY OF CYTOKINE PROFILE IN ATOPIC DERMATITIS PATIENTS
Author(s) -
Е Е Варламов,
O G Elisyutina,
Т В Виноградова,
Е С Феденко,
А Н Пампура
Publication year - 2016
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja358
Subject(s) - eotaxin , atopic dermatitis , medicine , cytokine , immunology , chemokine , dermatology , inflammation
Background. In this article the results of own research of the cytokine profile in atopic dermatitis (AD) adults and children depending on age are provided. Materials and methods. 88 patients with AD (54 children aged from 1 year to 16 years old and 24 adults aged from 21 years to 56 years old) were included in the study. Cytokine profile of a number of cytokines: IL-4, IL-5, IL-22, IL-31, IL-33, and transforming growth factor TGFβ1, eotaxin, eotaxin2 was examined. Results. Significant differences in IL-22, CC chemokines (eotaxin and eotaxin-2) and TGFβ levels depending on the age and severity of atopic dermatitis were found.