THE STUDY OF BALANCE OF Th1/Th2 IMMUNE RESPONSE DURING VIRUS-INDUCED ASTHMA EXACERBATION | Zendy

А. Р. Гайсина | Zendy; I.P. Shilovskiy | Zendy; Alexandra Nikonova | Zendy; M. S. Sundukova | Zendy; M A Zaretskaia | Zendy; Smirnov Vv | Zendy; O Y Kamishnikov | Zendy; A S Ivanova | Zendy; Musa Khaitov | Zendy

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THE STUDY OF BALANCE OF Th1/Th2 IMMUNE RESPONSE DURING VIRUS-INDUCED ASTHMA EXACERBATION

Author(s) -

А. Р. Гайсина,

I.P. Shilovskiy,

Alexandra Nikonova,

M. S. Sundukova,

M A Zaretskaia,

Smirnov Vv,

O Y Kamishnikov,

A S Ivanova,

Musa Khaitov

Publication year - 2016

Publication title -

russian journal of allergy

Language(s) - English

Resource type - Journals

eISSN - 2686-682X

pISSN - 1810-8830

DOI - 10.36691/rja347

Subject(s) - exacerbation , asthma , immunology , immune system , virus , medicine , respiratory system , population , asthma exacerbations , virology , environmental health

Bronchial asthma (BA) is the most common chronic disease of the airways affecting up to 18% of population in different regions of the world. Respiratory viruses such as rhinoviruses and respiratory syncytial virus (RSV) are the main causes of BA exacerbations. Current data demonstrate the major role of Th1- and Th2-response and corresponding cytokines in the development of infectious and allergic inflammation of the airways. At the same time, there are no data available concerning changes in Th1/Th2-balance during virus-induced asthma exacerbations. In the current study, we evaluated Th1/Th2-balance using developed mouse model of RSV-induced BA exacerbation. In was demonstrated, that RSV infection does not increase Th2-immune response but enhances Th1-response that shifts Th1/Th2-balance towards Th1.

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