Open AccessRole of skin microbiome in epidermal barrier dysfunction and development of atopic dermatitis in high risk infants
Author(s) -
Н.Б. Мигачева,
Мигачёва Наталья Бегиевна
Publication year - 2019
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja26
Subject(s) - atopic dermatitis , transepidermal water loss , microbiome , dermatology , colonization , medicine , skin barrier , staphylococcus aureus , incidence (geometry) , risk factor , barrier function , skin infection , immunology , biology , pathology , microbiology and biotechnology , bioinformatics , bacteria , genetics , physics , stratum corneum , optics
Background. Colonization of skin with S. aureus in atopic dermatitis (AD) patients is a widespread phenomenon and a factor complicating the course of the disease. At present, it is not quite clear the role of S. aureus in the development of AD in children at risk. The aim of our study was to discribe the skin microbiome composition in young children at risk, as well as to investigate the role of S. aureus in skin barrier dysfunction and the development of AD. Material and methods. 12months follow-up study of 37 infants at risk has been performed. It included a general clinical examination, a microbiological investigation of skin microbiome (at 1 and 6 months), and investigation of epidermal barrier function by determining the transepidermal water loss (TEWL) at 1, 3, 6 and 12 months. Realization of AD during the observation period was considered as main outcome. Results. The prevalence of S. aureus colonization of infants aged 1 month was 45.9%, at the age of 6 months - 29.7%. Correlation analysis revealed an association between the skin colonization with S. aureus and a decrease of TEWL (p = 0.004), as well as the cumulative incidence of AD (p