Open AccessDiagnostic and treatment algorithm for different phenotypes of chronic rhinosinusitis with nasal polyps
Author(s) -
Е. Л. Савлевич,
M.E. Dyneva,
Л. Е. Гаганов,
Viacheslav Egorov,
А. Н. Герасимов,
О М Курбачева
Publication year - 2019
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja1198
Subject(s) - medicine , nasal polyps , chronic rhinosinusitis , eosinophil , asthma , sinusitis , allergy , gastroenterology , nasal cavity , dermatology , endotype , immunology , surgery
Chronic rhinosinusitis with nasal polyps (CRSwNP) may vary in clinical manifestations and can often be associated with a number of comorbid diseases. For a practitioner it is important to forecast the development of the disease, evaluate the risk of relapse and select the most efficient method of treatment in each clinical case. At present, there are no standardized and validated diagnostic biomarkers that could be used as predictors of CRSwNP clinical course. Purpose of the study: to develop diagnostic and treatment algorithm for varies CRSwNP phenotypes based on clinical and laboratory parameters. Materials and methods, CRSwNP patients were split into 3 groups: group 1 - CRSwNP without allergy and asthma; group 2 - CRSwNP with allergic rhinitis and/or allergic asthma; group 3 - CRSwNP with non-allergic asthma. All patients were subjected to nasal cavity endoscopy and nasal polyps biopsy, allergological examination, histological analysis of polyp stroma to detect the leukocytes infiltration and eosinophil-neutrophil index (ENI). Results, CRSwNP phenotypes show significant difference in clinical manifestations of rhinosinusitis (p