Open AccessSerum periostin level in children of preschool age with recurrent wheezing episodes and in healthy children: a cross-sectional study
Author(s) -
Н В Шахова,
Шахова Наталья Викторовна,
Е. М. Камалтынова,
Камалтынова Елена Михайловна,
O.I. Kolesnikova,
Колесникова Ольга Ивановна,
T.S. Kashinskaya,
Кашинская Татьяна Сергеевна
Publication year - 2019
Publication title -
rossijskij allergologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2686-682X
pISSN - 1810-8830
DOI - 10.36691/rja1197
Subject(s) - periostin , medicine , quartile , pediatrics , asthma , cross sectional study , pathology , confidence interval , extracellular matrix , biology , microbiology and biotechnology
Background. The level of serum periostin in preschool children with recurrent wheezing episodes has been studied. Objective. To determine the serum periostin level in preschool children with recurrent wheezing episodes, compared to healthy children. Results. 101 children of 3-4 years old took part in the study, 72 of them had recurrent wheezing episodes (more than 3 episodes over the past year) and 29 - healthy individuals. Statistically significant differences in serum periostin level between children with recurrent wheezing episodes and healthy children were not found. The level of serum periostin (median, quartile) is 3.0 (1.8; 4.0) ng/ml in children with recurrent wheezing episodes and 2.7 (1.7; 3.6) ng/ml in healthy children (p=0.296). The area under the ROC curve (AUC) was 0.56 (95% CI 041-0.68). Conclusion. The level of serum periostin in children with recurrent wheezing episodes does not differ from the level in healthy children.