Influence of sublingual allergen-specific immunotherapy on dynamics of immunological parameters in patients with pollinosis | Zendy

M V Manzhos | Zendy; E S Fedenko | Zendy; M. А. Myagkova | Zendy; Б. А. Молотилов | Zendy; S A Shkadov | Zendy; С. Н. Петроченко | Zendy; Raisa Y. Kiseleva | Zendy

Open Access

Influence of sublingual allergen-specific immunotherapy on dynamics of immunological parameters in patients with pollinosis

Author(s) -

M V Manzhos,

E S Fedenko,

M. А. Myagkova,

Б. А. Молотилов,

S A Shkadov,

С. Н. Петроченко,

Raisa Y. Kiseleva

Publication year - 2009

Publication title -

russian journal of allergy

Language(s) - English

Resource type - Journals

eISSN - 2686-682X

pISSN - 1810-8830

DOI - 10.36691/rja1033

Subject(s) - immunology , immunoglobulin e , allergen , medicine , antibody , saliva , immunotherapy , allergen immunotherapy , allergy , immune system

Background. To study the influence of sublingual allergen-specific immunotherapy (slASIT) on dynamics of immunologic parameters in patients with pollinosis.Materials and methods. 40 healthy persons and 25 pollinosis patients received slASIT course with mixt of autumn grasses allergen. IgA, IgM, IgG, IgE antibodies, slgA, albumin in saliva and IgA, IgM, IgG, IgE antibodies, total IgE, IFN-γ, IL-4 in serum were investigated.Results. Patients with pollinosis have infringements of both local and general immunity. SlASIT changes a profile of cytokines aside Th-1, stimulates formation of the secretory allergen-specific antibodies, reduces IgE antibodies in saliva.Conclusion. SlASIT is a highly effective method of allergic diseases treatment and it induces B-cellular and T-cellular tolerance.

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