Open AccessClinical and immunological features of new coronaviral infection SARS-COV-2 in pregnant women (review)
Author(s) -
K. S. Lyazgiyan
Publication year - 2021
Publication title -
bûlletenʹ fiziologii i patologii dyhaniâ
Language(s) - English
Resource type - Journals
ISSN - 1998-5029
DOI - 10.36604/1998-5029-2021-80-91-99
Subject(s) - immune system , pregnancy , cytokine storm , medicine , immunology , fetus , preeclampsia , coronavirus , covid-19 , physiology , obstetrics , biology , disease , genetics , infectious disease (medical specialty)
The article provides a brief review of the PubMed and Google Scholar databases on the clinical and immunological features of the course of the COVID-19 in pregnant women caused by SARS-CoV-2. The significance of physiological changes in the body of a pregnant woman, namely, an increase in the metabolic rate and oxygen consumption, a decrease in the functional residual capacity, in the adaptability of the immune response in pregnant women to infection is shown. The factors are described that allow pregnant women to be included in the risk group for the development of a COVID-19, such as a decrease in the immune response due to a semi-allogeneic fetus, preeclampsia, as well as a cytokine storm during the pro-inflammatory period of pregnancy. The analysis of the world literature data concerning the clinical and immunological features of the new coronavirus infection in pregnant women made it possible to conclude that the issue of developing an effective method for modulating the immune response by the body of a pregnant woman is insufficiently studied.