
Study of anaesthetical activity of alkoxyphenylcarbamic acid esters using statistical methods
Author(s) -
Tatiana Ďurčeková,
Ján Mocák,
J. Lehotay,
J Čižmárik
Publication year - 2022
Publication title -
nova biotechnologica et chimica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.212
H-Index - 9
eISSN - 1339-004X
pISSN - 1338-6905
DOI - 10.36547/nbc.1368
Subject(s) - chemistry , lipophilicity , alkoxy group , molar mass , chromatography , principal component analysis , partition coefficient , organic chemistry , alkyl , polymer , artificial intelligence , computer science
Anaesthetical activity of 113 morpholinoethyl-, piperidinoethyl-, piperidinopropyl- and azepanoethyl- ester derivatives of alkoxyphenylcarbamic acid was characterized by several chemometrical techniques. The surface anaesthetical activity, A, and the infiltration anaesthetical activity, B, were correlated to lipophilicity, (expressed by the logarithm of the HPLC retention factor, log k), the length of the side alkoxy chain (represented by the number n of carbon atoms), molar mass M as well as the ester type. Principal component analysis and cluster analysis were used for predicting both types of the anaesthetic activity of the alkoxyphenylcarbamic acid esters.