Open AccessApplications substituted 2-aminothiophenes in drug design
Author(s) -
Zita Puterová,
A. Krutošíková,
Dániel Végh
Publication year - 2021
Publication title -
nova biotechnologica et chimica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.212
H-Index - 9
eISSN - 1339-004X
pISSN - 1338-6905
DOI - 10.36547/nbc.1274
Subject(s) - chemistry , antimicrobial , thiophene , allosteric regulation , combinatorial chemistry , drug , pharmacology , biochemistry , organic chemistry , receptor , biology
Highly substituted thiophene derivatives are important heterocycles found in numerous biologically active compounds. Title compounds are attractive derivatives because their applications in pharmaceuticals, agriculture and pesticides. They exhibit antimicrobial activity against various Gram(+) and Gram(-) bacteria and fungi. Many of these molecules act as allosteric enhancers of A1-adenosine receptor, glucagon antagonists as well as antioxidant and anti-inflammatory agents.