Open AccessReactions of 4-hydroxycoumarin with heterocyclic aldehydes
Author(s) -
Renata Gašparová,
Katarína Kotlebová,
Margita Lácová
Publication year - 2021
Publication title -
nova biotechnologica et chimica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.212
H-Index - 9
eISSN - 1339-004X
pISSN - 1338-6905
DOI - 10.36547/nbc.1146
Subject(s) - chemistry , acetic anhydride , acetic acid , dichloromethane , toluene , sodium hydroxide , 4 hydroxycoumarin , organic chemistry , microwave irradiation , hydroxyl value , ethyl formate , catalysis , solvent , polyol , polyurethane
Reactions of 4-hydroxycoumarin 1 with heterocyclic aldehydes 2-4 led to bis-4-hydroxycoumarin derivatives 5-7 under microwave irradiation as well as under the classical heating. The subsequent reactions of products 5-7 are described. 4,4’-Epoxydicoumarins 8, 9 were prepared by the reaction of 5-7 in acetic acid / p-toluenesulfonic acid medium. Compound 10 was prepared by the reaction of 5 in acetic anhydride in the presence sodium acetate. Dioxocine-1,15-dione 11 was prepared by the reaction of 6 with dichloromethane in sodium hydroxide-toluene.