Reactions of 4-hydroxycoumarin with heterocyclic aldehydes | Zendy

Renata Gašparová | Zendy; Katarína Kotlebová | Zendy; Margita Lácová | Zendy

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Reactions of 4-hydroxycoumarin with heterocyclic aldehydes

Author(s) -

Renata Gašparová,

Katarína Kotlebová,

Margita Lácová

Publication year - 2021

Publication title -

nova biotechnologica et chimica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.212

H-Index - 9

eISSN - 1339-004X

pISSN - 1338-6905

DOI - 10.36547/nbc.1146

Subject(s) - chemistry , acetic anhydride , acetic acid , dichloromethane , toluene , sodium hydroxide , 4 hydroxycoumarin , organic chemistry , microwave irradiation , hydroxyl value , ethyl formate , catalysis , solvent , polyol , polyurethane

Reactions of 4-hydroxycoumarin 1 with heterocyclic aldehydes 2-4 led to bis-4-hydroxycoumarin derivatives 5-7 under microwave irradiation as well as under the classical heating. The subsequent reactions of products 5-7 are described. 4,4’-Epoxydicoumarins 8, 9 were prepared by the reaction of 5-7 in acetic acid / p-toluenesulfonic acid medium. Compound 10 was prepared by the reaction of 5 in acetic anhydride in the presence sodium acetate. Dioxocine-1,15-dione 11 was prepared by the reaction of 6 with dichloromethane in sodium hydroxide-toluene.

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