Open AccessPrevalence of Helicobacter pylori infection in patients with Dementia who underwent Percutaneous Endoscopic Gastrostomy (PEG) and the effect of preventive single dose ceftrixone plus pantaprazole therapy on Helicobacter pylori infection
Author(s) -
Taner Akyol,
Ahmet Cumhur Dülger,
Yaren Dirik,
Demet Şeker,
Vedat Ataman Serim,
Hüsniye Aylin Hakyemez,
Tuğrul Kesicioğlu,
Muhammed Ali Ayvaz,
Merih Şimşek
Publication year - 2022
Publication title -
medical science and discovery
Language(s) - English
Resource type - Journals
ISSN - 2148-6832
DOI - 10.36472/msd.v9i3.686
Subject(s) - medicine , pantoprazole , percutaneous endoscopic gastrostomy , dementia , gastroenterology , helicobacter pylori , retrospective cohort study , creatinine , surgery , peg ratio , disease , omeprazole , finance , economics
Objective: This was a retrospective study of the hospital database from April 2020 to January 2021 to reveal the rate of Helicobacter pylori infection among Dementia patients who underwent percutaneous endoscopic gastrostomy (PEG) procedure. Other aim of this study is examine the effect of a single dose (two grams) intravenous ceftriaxone plus pantoprazole (40 mg) before PEG procedure on H.pylori infection in Dementia patients.Material and Methods: This is a retrospective observational study of hospital database from April 2020 to January 2021 examining the effect of using a single dose (two grams) of intravenous ceftriaxone plus pantoprazole (40 mg) on H.pylori infection in Dementia patients. A total of 77 patients, (43 (64%) of them were female) with Dementia were included whose 67 had previously been diagnosed as Dementia and underwent PEG procedure. The control group (67 subjects; 40 of them were female and the mean age was 75.8±11 years) was selected from age and gender-matched dyspeptic subjects who underwent endoscopyResults: While the mean age in the Dementia group was 75.8±12 years, the mean age of the control group was 77.8 ±11 years (p=0.054). There were also no gender differences between groups (p=0.594).While the mean levels of serum albumin, urea, creatinine, hemoglobin were significantly lower than control subjects (All p values were below 0.001), the mean of serum ferritin level was higher than control subjects (p<0.01). The presence of H.pylori on gastric biopsy specimens was significantly lower in the Dementia group compared to control subjects (19.4% versus 55.2%).Conclusion: Our study indicated that the rate of H.pylori infection was lower than estimated and using single-dose intravenous ceftriaxone at a dose of 2 grams could be beneficial for treating H.pylori infection in patients with Dementia who faced difficulties related to lack of swallowing many drugs against H.pylori infection.