Open AccessCan changes in platelet count, mean platelet volume, and platelet distribution width be used to determine the severity of COVID-19?
Author(s) -
Yasin Tire,
Mehmet Akif Yazar,
Sami Erdem
Publication year - 2021
Publication title -
medical science and discovery
Language(s) - English
Resource type - Journals
ISSN - 2148-6832
DOI - 10.36472/msd.v8i10.611
Subject(s) - medicine , mean platelet volume , platelet , thrombocytosis , white blood cell , red blood cell distribution width , covid-19 , intensive care unit , gastroenterology , c reactive protein , platelet activation , immunology , inflammation , disease , infectious disease (medical specialty)
Objective: We aimed to investigate the relation of platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) with other acute phase reactants in COVID-19 new corona virus.
Material and Methods: Thirty one patients with COVID-19 were included in to study. There were three groups as outpatient (Group 1, OP)(n=6), hospital (Group 2, H)(n=16) and intensive care unit (Group 3, IC)(n=9) in this analytic study.
Results: WBC (White Blood Cell), CRP (C-Reactive Protein) values were significantly different in all groups. PDW values were significantly lower in Group 3 than Group 1, 2. The result of ROC analysis was 10.9 as a cut-off value (Area under the curve, AUC)=0.407)
Conclusions: This study indicates that lower PDW may frequently develop in COVID-19 cases and there is a relation between thrombocytosis and acute phase reactants, that is, the inflammatory response. So we can offer that PDW should be used as a marker of Covid-19 disease severity, but it needs more studies in the future.