Open AccessPrognostic factors and curative radiotherapy results in patients with octogenarian bladder cancer
Author(s) -
Berrin İnanç,
Özlem Mermut
Publication year - 2020
Publication title -
medical science and discovery
Language(s) - English
Resource type - Journals
ISSN - 2148-6832
DOI - 10.36472/msd.v7i6.386
Subject(s) - medicine , hazard ratio , radiation therapy , proportional hazards model , chemoradiotherapy , stage (stratigraphy) , bladder cancer , univariate analysis , multivariate analysis , retrospective cohort study , cancer , confidence interval , surgery , oncology , paleontology , biology
Objective: In this retrospective research, we aimed to evaluate the survival outcomes and survival-related prognostic factors in octogenarian (>80 years) bladder cancer patients.
Material and Methods: A total of 17 patients receiving radiotherapy or chemoradiotherapy treatment for bladder cancer in octogenarian patients were included in the study.
Results: In total 17 patients, 13 patients (76.5%) had Stage II, 2 patients (11.8.%) had Stage III and stage IVa. Median follow-up was 23 months (6-72 months).While median overall survival (OS) was 14 months, median disease-free survival (DFS) was 13 months.Overall survival and disease-free survival rates for 6 months and 1st years were 70.6%, 35% and 64.3%, 24.1%, respectively. No prognostic factors were found in the univariate Cox regression analysis for overall survival. In multivariate Cox regression analysis, we found stage (hazard ratio [HR] = 3.009. 95% confidence interval [CI] = 1.003–9.029, p = 0.049), radiotherapy doses (HR = 241,226, 95% CI = 5.421–107.679, p = 0.005) and Charlson co-morbidity index (HR = 0.161 95% CI = 0.035–0.748, p = 0.020) as independent prognostic factors for overall survival.
Conlusion: Curative radiotherapy can be used for older ( >80 years) patients with invasive bladder cancer. Nonetheless, the co-morbidity disease should be a consideration before radiotherapy and chemoradiotherapy administration