Open AccessEffects of Thymus Vulgaris L. and Thymbra Spicata L. on diabetes mellitus associated cognitive impairment and neuropathy: Thymus Vulgaris and Cognitive Function Improvements
Author(s) -
Zafer Akan,
Melek Dikilidal,
Hülya Özdemir,
Gökhan Oto,
Ahmet Yılmaz
Publication year - 2019
Publication title -
medical science and discovery
Language(s) - English
Resource type - Journals
ISSN - 2148-6832
DOI - 10.36472/msd.v1i1.31
Subject(s) - medicine , diabetes mellitus , morris water navigation task , thymus vulgaris , cognitive decline , lamiaceae , endocrinology , traditional medicine , disease , food science , hippocampus , dementia , chemistry , essential oil
Aim: Diabetes mellitus (DM) is a metabolic disease due to increased blood glucose, with multiple organ involvement. Although various oral drugs are used to treat DM, they do not prevent the development of DM related diseases such as cognitive disorder, neuropathy and vascular diseases. Thus novel strategies for the prevention and treatment of DM are urgently needed. This research aimed to reveal the effects of Thymus Vulgaris Lamiaceae (TVL) and Thymbra Spicata Lamiaceae (TSL) on the damaging effects of DM. Materials and Methods: Therefore, prepared TVL and TSL aqueous extracts were studied in the streptozocin induced experimental diabetic rat model. Blood glucose, body weight, and cognitive functions were examined. Morris water maze test was used to define the effect of TVL and TSL on DM related cognitive dysfunction. Results: Briefly, impaired blood glucose, and cognitive dysfunction of Diabetic rats were significantly improved by TVL in dose dependent manner (P