Open AccessSKRINING SENYAWA INHIBITOR H2 DARI KAYU MANIS (Cinnamomum verum J.Presl)
Author(s) -
Sutarto Hadi,
Diah Aulia Rosanti,
Desiya Ramayanti Azhara,
Kunti Nastiti
Publication year - 2021
Publication title -
jiis (jurnal ilmiah ibnu sina)
Language(s) - English
Resource type - Journals
eISSN - 2502-647X
pISSN - 2503-1902
DOI - 10.36387/jiis.v6i2.663
Subject(s) - stigmasterol , chemistry , docking (animal) , eugenol , traditional medicine , cinnamaldehyde , cinnamomum , protocatechuic acid , pharmacology , chromatography , biochemistry , biology , medicine , cassia , organic chemistry , antioxidant , traditional chinese medicine , alternative medicine , pathology , catalysis , nursing
Digestive tract disorders, especially gastric disorders, are often experienced by people. One drug to treat this disorder has a mechanism of blocking the H2 receptor. This research was conducted to find compounds from C.verum which have the stability of bind to H2 receptors. The method used is protein modeling with swiss-model, docking with PLANTS (CHEMPLP) and activity prediction. The test results obtained that the docking score was ?- amorphene (-65,79), ?-bergamotene (-65,48), ?-copaene (-66,62), ?-cubebene (-66,46), Cadinene (-64 , 79), Camphor (-52.15), Caryophyllene (-62.61), Cinnamaldehyde (-68.17), Epicatechin (-80.43), Ergosterol (-85.24), Eugenol (-67.35), Hydrocinnamaldehyde (-65,53), Quercetin (-74,38), Protocatechuic acid (-71,49), Stigmasterol (-88,88), 4- (2,3-dihydro-3- (hydroxymethyl) - 5- (3-hydroxypropyl) -7- (methoxy) benzofuranyl] -2-methoxyphenyl (-85,29). Combined with the probability activity of compounds that have the potential to be further developed are Epicatechin and urolignoside.