Open AccessAssociation of TNFRII polymorphisms and IL-37 in rheumatoid arthritis Iraqi patients
Author(s) -
Wasnaa J. Mohammad,
Noor Ibrahim,
Shahad F . Obed,
Shahad F . Obed,
Mohammed Sh. Jebur
Publication year - 2021
Publication title -
journal port science research
Language(s) - English
Resource type - Journals
eISSN - 2616-7220
pISSN - 2616-6232
DOI - 10.36371/port.2021.1.7
Subject(s) - rheumatoid arthritis , medicine , gastroenterology , immunology , genotype , case control study , arthritis , gene , biology , genetics
Fifty RA patients and 50 healthy individuals have been participated in this study. 196 M/R polymorphism of TNFRII gene determined by PCR-RFLP, IL-37 level was measured by ELISA technique, also RF, ACCP, CRP measured by ELISA technique. Our study shows an increase in IL-37 levels in patients was suffered from rheumatoid arthritis relative to control group. (M=101.31+10.41) That shows major differences between patients and controls (p<0.01) and increasing level of IL-37 correlate significantly with increasing level of CRP (p<0.05). The frequencies of TNFRII gene polymorphism were significantly correlate with the IL-37 level (p<0.01) in RA patients compared with control group. In conclusion, IL-37 increased in RA patients associated with disease development, also significantly associated with TNFRII polymorphism.