Open AccessProlymphocyte Leukemia: A Case Report
Author(s) -
Ghita Elghouat,
Abderrahim Raissi,
Hicham Yahyaoui,
Raja Nakhli,
Mohammed Chakour
Publication year - 2022
Publication title -
east african scholars journal of medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2617-7188
pISSN - 2617-4421
DOI - 10.36349/easms.2022.v05i02.009
Subject(s) - immunophenotyping , lymphocytosis , leukemia , hematopoietic stem cell transplantation , haematopoiesis , transplantation , medicine , monoclonal , pathogenesis , pathology , monoclonal antibody , immunology , stem cell , biology , antibody , flow cytometry , genetics
Prolymphocyte leukemia is a very rare, complex, and often aggressive, mature lymphoid hemopathy. The mean age of onset is 65 years with a predominance of males. We report here the case of a patient with splenomegaly and severe lymphocytosis in whom the smear showed an invasion of 90% of prolymphocytes suggesting Prolymphocyte leukemia confirmed by immunophenotyping. Both purine analogues and monoclonal antibodies have shown promoting results, however, allogeneic hematopoietic stem cell transplantation remains the only therapeutic means allowing a lasting response. However, it is reserved for young patients with compatible donors. A good understanding of the pathogenesis and a better integration of the molecular data of this hemopathy open the way to the use of new targeted therapies.