Open AccessHsCRP (High-Sensitivity C - reactive protein) and its Association with Short Term Prognosis Following Ischaemic Stroke
Author(s) -
Mohammed Momenuzzaman Khan,
Farhana Younus,
Mohammad Ibrahim Hossain,
Ayesha Tabassum Swarna,
Nelson Taposh Mondal,
Sajal Kumar Shil
Publication year - 2022
Publication title -
saudi journal of medical and pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2413-4929
pISSN - 2413-4910
DOI - 10.36348/sjmps.2022.v08i04.001
Subject(s) - medicine , stroke (engine) , c reactive protein , ischaemic stroke , neurology , disease , cardiology , ischemia , inflammation , mechanical engineering , psychiatry , engineering
Introduction: Stroke is a major cerebrovascular disease is one of the most common Neurological diseases. It is the second leading cause of death worldwide. Cerebrovascular disease threatening human health and life with high morbidity, disability and mortality. Major risk factors of ischaemic strokes are hypertension, diabetes, and dyslipidaemia. High sensitivity C-reactive protein (HsCRP) is an inflammatory marker which appears to be a strong predictor of risk factor and prognostic marker of Ischaemic stroke. Objective: To find the acute course of HsCRP and its association with short term prognosis following Ischaemic stroke. Methods: A Cross sectional observational study at Dept. of Neurology, Enam Medical College Hospital, Savar, Dhaka, Bangladesh From March 2020 to April 2021. Total number of subjects in this study were 101 with power 80% (persons aged 30 years & above; both male and female). Both sexes and their plasma high sensitivity C-reactive protein (HsCRP) level was measured within 48 hours of admission and on the 5th day after admission. Results: The study showed that the level of HsCRP did not change significantly when measured within 48 hours of onset of Ischaemic stroke and on 5th day after stroke (p=0.335) - the prognosis and severity remained same when followed for 5 days. It, also, showed that the level of CRP ≥ 3 within 48 hours of admission is associated with increased severity and mortality of stroke (Z=14.4; p<0.0001). Conclusion: HsCRP level provides rapid and reliable information regarding severity & prognosis in patients with Ischaemic stroke. The level of HsCRP does not change significantly when measured within 48 hours of onset of Ischaemic stroke and on 5th day after stroke. Also, the level of CRP on 5th day was same as within 48 hours of stroke - the prognosis and severity remained same. If confirmed by larger, longitudinal studies this association may be used as a tool to assess the severity and prognosis in a patient with Ischaemic strokes.