Open AccessPsoriasis Vrs Cassia Fistula: In-Silico Study
Author(s) -
Mr. Chandra Sekhar Tripathy,
Anil Kumar,
Prof. Ghassem Habibi Bibalani,
Santosh Kumar Behera,
Santanu Kumar Budhia,
P K Mohanta,
Easter Khura,
Asadollah Asadi,
Arash Abdolmaleki,
Prof. Muhammad Akram,
Debasish Mishra,
D. K. Bhattacharya
Publication year - 2022
Publication title -
saudi journal of medicine
Language(s) - English
Resource type - Journals
eISSN - 2518-3397
pISSN - 2518-3389
DOI - 10.36348/sjm.2022.v07i03.005
Subject(s) - psoriasis , cassia , in silico , transient receptor potential channel , dermatology , chemistry , medicine , pharmacology , biochemistry , receptor , pathology , alternative medicine , traditional chinese medicine , gene
Psoriasis is a skin disease. It is rare growing disease around the world. Here in this investigation we have targeted a protein namely TRPV3 (Transient receptor potential cation channel, subfamily III) ion channel for the study of psoriasis, which is important factor of psoriasis. The medicinal plant namely Cassia fistula is selected for the in silico investigation. 39 phyto compounds as reported in various research papers are taken for study. Out of 39 phytochemicals, Chrysophanol compound showed highest binding affinity of -7.58kcal/mol having 3 conventional Hydrogen bonds with TRPV3 protein and is found to be a better natural compound as compared to other reported drugs generally used to for the psoriasis. This investigation will lead to more and better findings leading to drug discovery & use as functional food.