Open AccessAssociation of Factor V Leiden Mutation with Unexplained Recurrent Pregnancy Loss
Author(s) -
Sanjukta Chowdhury,
Mehar Sultana,
Surayea Bulbul,
Ferdous Ara Banu,
Prof. Nahreen Akhtar,
Prof. Firoza Begum
Publication year - 2022
Publication title -
scholars international journal of obstetrics and gynecology
Language(s) - English
Resource type - Journals
eISSN - 2617-3492
pISSN - 2616-8235
DOI - 10.36348/sijog.2022.v05i03.001
Subject(s) - medicine , pregnancy , factor v leiden , risk factor , obstetrics , gynecology , gastroenterology , pediatrics , thrombosis , venous thrombosis , genetics , biology
Recurrent pregnancy loss (RPL) is considered as a significant public health problem. In many studies, Factor V Leiden mutation is considered to have significant relationship with unexplained recurrent pregnancy loss. Aim of the study: The aim of this study was to determine the association of Factor V Leiden mutation with unexplained recurrent pregnancy loss. Methods: This case-control study was conducted in the out-patient Department of Fetomaternal Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, from November 2020 to April 2021 (6 months). Sample size was taken as 40 for each case and healthy control group. Result: Mean (±SD) age was found 28.2±4.9 years in RPL group and 27.1±5.24 years in non-RPL group. Maximum number of patients fell into the BMI category of 23.0-26.9 kg/m2 (BMI for Asian women) in both groups. Among the RPL cases, 30% had experienced consecutive 2 pregnancy losses with mean (±SD) number of losses 3.07±1.14. About more than half percentages (n=23, 57.5%) shared the primary RPL group. In this study, normal homozygous FVL mutation was equally distributed among RPL patients and control individuals. Only 2 cases (5%) were found positive for Factor V heterozygous mutation (GA) in the RPL group. G allele occurred in most of the cases (97.5%) of RPL. Two cases aged 25 years and 35 years respectively were found positive for heterozygous mutation of Factor V Leiden. Both of them exhibited 3 consecutive recurrent second trimester pregnancy losses. Factor V Leiden was found in higher prevalence (100%) in 2nd trimester recurrent pregnancy loss sub-group of cases and revealed significant association (p <0.001) between two variables. Conclusion: The impact of Factor V Leiden mutation has not stated any causal association with unexplained recurrent pregnancy loss. The results do not support Factor V mutation screening as an initial approach in Bangladeshi women suffering from recurrent pregnancy loss.