Open AccessSynthesis and Identification of New Heterocyclic Compounds from Isatin by Schiff Base Reaction
Author(s) -
Intisar Obaid Alfatlawi,
Faez Abdul-Hussein Al-Rammahi,
Khalida K. Abbas Al- Kelaby
Publication year - 2022
Publication title -
global academic journal of pharmacy and drug research
Language(s) - English
Resource type - Journals
eISSN - 2707-255X
pISSN - 2706-9044
DOI - 10.36348/gajpdr.2022.v04i01.004
Subject(s) - isatin , heteroatom , chemistry , cycloaddition , ring (chemistry) , heterocyclic compound , organic chemistry , sulfur , schiff base , indole test , combinatorial chemistry , polymer chemistry , catalysis
Heterocyclic compounds possess a cyclic structure with two or more different kinds of atoms in the ring. The history of heterocyclic chemistry began in the 1800s, in step with the development of organic chemistry. Since rings can be of any size, from three-membered upwards, and since the heteroatoms can be drawn in almost any combination from a large number of the elements (though nitrogen, oxygen, and sulfur are still by far the most common), the number of possible heterocyclic systems is almost limitless. An enormous number of heterocyclic compounds are known and this number continues to increase very rapidly. This work is divided into two different parts: First part: Synthesis of imines by Schiff base reaction, this part involves synthesis three of imines by treatment isatin with a variety of cyclo primary amines. Second part: [3 + 2] Cycloaddition reaction, this part includes reacting each product of the first part with two types of amino acids. All steps of reactions followed by TLC– papers. All synthesized compounds were confirmed through the use of different spectroscopic techniques (IR and NMR), melting points.