Open AccessBroadening the Factor V Leiden Paradox: Pulmonary Embolism and Multisystemic Arterial Thrombosis as 2 Sides of the Spectrum
Author(s) -
L Rachid,
R Zerhoudi,
M El Jamili,
S l Karimi,
M El Hattaoui
Publication year - 2022
Publication title -
scholars journal of applied medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2347-954X
pISSN - 2320-6691
DOI - 10.36347/sjams.2022.v10i04.033
Subject(s) - factor v leiden , medicine , cardiology , thrombosis , thrombus , pulmonary embolism , venous thrombosis , clotting factor , stroke (engine) , embolism , pulmonary infarction , context (archaeology) , mechanical engineering , paleontology , engineering , biology
Factor V Leiden mutation is an inherited disorder of coagulation. Factor V Leiden resists the effects of activated protein C, so it takes longer to turn off Factor V Leiden. As a result, clotting goes on longer than usual. It’s associated with thrombotic events that classically involve the venous thrombosis and rarely arteries. However, the role of factor V Leiden in the genesis of arterial thrombosis is not yet fully understood. We report a case of a young woman with multiple thromboembolic events including pulmonary embolism, renal associated to hepatic infarction, apical thrombus on the left ventricle and ischemic stroke, in the context of a factor V mutation.