Open AccessMedullomyoblastoma: A Case Report and Literature Review of a very Rare Variant of Medulloblastoma
Author(s) -
Mohamed Allaoui,
Mustapha Azzakhmam,
Mohamed Amine Es-Saoudi,
Mohamed Réda El Ochi,
Amal Damiri,
Hafsa Chahdi,
Mohammed Oukabli
Publication year - 2022
Publication title -
scholars journal of applied medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2347-954X
pISSN - 2320-6691
DOI - 10.36347/sjams.2022.v10i04.012
Subject(s) - medulloblastoma , desmin , pathology , cerebellar vermis , magnetic resonance imaging , joubert syndrome , immunohistochemistry , medicine , myogenin , lesion , histogenesis , cerebellum , histopathological examination , anatomy , radiology , biology , vimentin , gene , biochemistry , myogenesis , skeletal muscle
Medullomyoblastoma is an extremely rare tumor, corresponding to a variant of medulloblastoma with rhabdomyoblastic differentiation. Both tumor populations are sharing the same genetic alterations. We report a case of a 10 year-old girl, admitted for symptoms of intracranial hypertension associated with a cerebellar syndrome. Magnet resonance imaging of the brain was performed, and revealed a lesion of the cerebellar vermis. A wide excision was performed and the histopathological examination objectified a densely round cells proliferation coexisting with nests of rhabdomyoblastic cells that express desmin and myogenin in immunohistochemistry, making the diagnosis of medullomyoblastoma.