Open AccessShortened Coagulation Profile in Pregnancy
Author(s) -
S. Balaji,
Kalla Ravi Teja,
Govindaraj TB,
Amirtha Sivani
Publication year - 2022
Publication title -
scholars journal of applied medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2347-954X
pISSN - 2320-6691
DOI - 10.36347/sjams.2022.v10i01.018
Subject(s) - pregnancy , medicine , coagulation , obstetrics , coagulation system , disseminated intravascular coagulation , postpartum period , gynecology , genetics , biology
Hyper-coagulation and low grade disseminated intravascular coagulation exists during the entire period of pregnancy and immediate postpartum period. The hormonal changes in pregnancy maintains the placental function during the entire pregnancy and also during delivery, this is achieved by the significant changes in coagulation system during pregnancy; increases in levels of clotting factors, decreased concentration of anticoagulants and diminishing fibrinolytic activities, leading to the state of hypercoagulability. Study and result: The study was done in Central lab, Department of Pathology of our Institute. In this study, the PT and APTT levels of 150 pregnant women during different trimesters of pregnancy and labor were studied and we got a outcome of shortened profile in 104 patients out of which cases with shortened PT is 34%, shortened APTT is 51%, shortened PT and APTT is 15%. Implication: With the knowledge of the reference level, Shortened APTT independently predicts the first episodes and also subsequent recurrence of venous thromboembolism (VTE) and Post-partum hemorrhage.