Open AccessGastrointestinal Bleeding and Non-Steroidal Anti-Inflammatory Drugs in Hospitals in Bamako, Mali
Author(s) -
Dicko M. Y,
D Katile,
Tounkara M. S,
G Soumare,
N Doumbia,
Doumbia K Épouse Samake,
Sow H Épouse Coulibaly,
Sanogo D Épouse Sidibe,
M Keita,
A Konate,
Diarra M. T,
Maiga M. Y
Publication year - 2022
Publication title -
sas journal of medicine
Language(s) - English
Resource type - Journals
ISSN - 2454-5112
DOI - 10.36347/sasjm.2022.v08i04.024
Subject(s) - medicine , context (archaeology) , drug , diclofenac , gi bleeding , gastroenterology , shock (circulatory) , prospective cohort study , endoscopy , anesthesia , pharmacology , paleontology , biology
The main aim of this study was to investigate the role of non-steroidal anti-inflammatory drugs in digestive bleeding in a hospital setting and in a context of social and security instability. Patients and methods: This was a prospective and analytical study that took place in the Hepato-Gastroenterology Department of the Gabriel TOURE University Hospital over a period of two years and included all patients hospitalized for digestive hemorrhage. These patients had benefited from the research of sociodemographic characteristics, the notion of taking non-steroidal anti-inflammatory drugs (dose and duration), a physical examination and a digestive endoscopy. Results: At the end of this study, 78 cases of non-steroidal anti-inflammatory drug use out of 210 patients hospitalized for digestive hemorrhage were recorded, i.e. a frequency of 37.1%. The mean age of our patients was 47.01±19.3 years with a sex ratio of 2.9. Housewives and farmers represented 28.2% and 20.5% respectively. Hematemesis was the reason for consultation in 71.8%. Digestive hemorrhage and smoking were the most common antecedents. Diclofenac was the most commonly used drug in 53.9% of cases, with bleeding occurring in the first week after taking the non-steroidal anti-inflammatory drug in 53.9% of cases. Signs of hypovolemic shock were frequently found. The GD ulcer was the cause found in 66.2% of cases. Hemorrhage occurred significantly (p=10-8) in the first week of taking non-steroidal anti-inflammatory drugs and was significantly associated with NSAID use. There was no statistically significant difference in the occurrence of death between the molecules. Conclusion: NSAID-induced GI bleeding in adults is one of the major GI emergencies and remains an important cause of morbidity and mortality.