Open AccessImportance of the Functional Biomarker FEF 25%-75% in the Evaluation of Children and Adolescents with Asthma Sensibilized to House Dust Mites
Author(s) -
Davisson Tavares,
Cyro Teixeira da Silva,
Adriana Álvarez,
Priscilla Filippo Alvim de Minas Santos,
Bernardo Henrique Ferraz Maranhão,
Selma Maria de Azevedo Sias
Publication year - 2022
Publication title -
sas journal of medicine
Language(s) - English
Resource type - Journals
ISSN - 2454-5112
DOI - 10.36347/sasjm.2022.v08i04.017
Subject(s) - asthma , medicine , dust mites , house dust mite , airway obstruction , small airways , sensitization , biomarker , vital capacity , airway , immunoglobulin e , pediatrics , allergy , immunology , anesthesia , allergen , antibody , lung , lung function , biochemistry , chemistry , diffusing capacity
The GINA and the ATS do not mention that the forced expiratory flow between 25% and 75% of forced vital capacity (FEF 25%-75%) play importance in evaluation of airflow obstruction in asthma. Objectives: To investigate whether the evaluation of the FEF25%-75% in children and adolescents with asthma sensibilized to house dust mites (HDM) plays an important hole in airway obstruction from small airways. Methods. A retrospective study was done in Hospital Municipal Jesus (Rio de Janeiro, Brazil). Thirty-four children and adolescents with asthma were enrolled between January 2016 and December 2019. The FEIA (Immuno CAP®) was used to measure total and specific IgE antibodies to HDM. Standard reference value for small airways diseases with FEF 25%-75% was considered abnormal if below at 65% of predicted with FEV1/FVC ratio above or equal at 80%. Results. There was a significant difference between the mean ages of the sensitized (n=26; 9.8±2.53) and non-sensitized participants (n=8; 7.75±1.28) to HDM (P=0.0353). Male and female sexes were not significant in both groups (P=0.3698 and P=0.3298, respectively). If the FEF 25%-75% (L/s) was not valued in our study, 62% of sensitized participants (44.27±9.26) and 38% not sensitized (56.62±16.56) to HDM would be considered “according to normal reference values” (t=1.86; P=0.0719). Conclusions. The asthma in this study presented an obstructive respiratory disorder of small airways, regardless of a sensitization or a non-sensitization to HDM. The obstructive respiratory disorder of small airways was present, even with normal spirometry in the evaluation of large airways.