Open AccessComparative Study of the Therapeutic Effect of Nigella Sativa Vaginal Suppository against Clotrimazole Vaginal Cream among Women with Candida Albicans Infection
Author(s) -
Golsoum Sourazar
Publication year - 2022
Publication title -
scholars academic journal of pharmacy
Language(s) - English
Resource type - Journals
eISSN - 2347-9531
pISSN - 2320-4206
DOI - 10.36347/sajp.2022.v11i03.002
Subject(s) - clotrimazole , nigella sativa , medicine , suppository , candida albicans , vaginal discharge , gynecology , pharmacology , traditional medicine , dermatology , antifungal , microbiology and biotechnology , biology
Objective and Background: Candida Albicans is responsible for 90% of vaginal fungal infections. This study aimed at comparison of the therapeutic effect of Nigella Sativa vaginal suppository against Clotrimazole vaginal cream among women with Candida Allicans vaginal infection. Materials and Methods: This interventional study is an analysis performed on 68 non-pregnant women suffering from Candida Albicans infection who referred to Alavi Hospital in Ardabil. They were divided into two equal groups of 34 people including Nigella Sativa (intervention group) and Clotrimazole vaginal cream (control group). Clinical and experimental symptoms and signs were observed and recorded by a questionnaire and form at the beginning of the study and after treatment. Treatment was performed in both groups for 7 nights. Data was analyzed by one-way ANOVA, t-test and McNemar Test. Results: The results of the study showed that the rate of improvement and treatment failure in the intervention and control groups was 86.30%-14.70% and 58.82%-41.18%, respectively. There was a significant difference between the two groups (p<0.002). Conclusion: The present study showed that Nigella Sativa vaginal suppository provides a more effective therapeutic effect on Candida Albicans vaginal infection compared to Clotrimazole vaginal cream.