Open AccessCORRELATION OF CREATINE KINASE AND MYOGLOBIN CONCENTRATIONS IN PATIENTS SUFFERING FROM DEBILITATED CONDITIONS RELATED TO MYOPATHIES
Author(s) -
Junaid Mahmood Alam,
Amna Hussain,
Sumaira Imran Farooqui,
Syed Riaz Mahmood
Publication year - 2012
Publication title -
pakistan journal of rehabilitation
Language(s) - English
Resource type - Journals
eISSN - 2311-3863
pISSN - 2309-7833
DOI - 10.36283/pjr.zu.1.1/002
Subject(s) - myoglobin , creatine kinase , dermatomyositis , polymyositis , medicine , myopathy , gastroenterology , cardiology , correlation , cohort , endocrinology , biochemistry , chemistry , geometry , mathematics
The present study describes the determination of a possible correlationbetween CK and myoglobin levels, in addition to the hypothesis that increase inmyoglobin concentrations may precede changes in CK levels in patientssuffering from myopathies.The inclusion period for this cohort study was from December 2005 to December2007. Patients who met the laid down and referred criteria were eligible for thestudy, which includes patients aged > 20 years to < 75 years (both gender) andhad a diagnosis of myopathies as per description. Standard protocols werefollowed for blood samples collection and estimation of aldolase, CK AST, ALT,CK and myoglobin levels. Regression correlations were determined and resultswere compared as per R2 and significance level P < 0.05.A total of 48 patients were included in the study, males = 32 (66.66%) andfemales = 16 (33.33%). Except for both CK and myoglobin, the rest of theenzymatic components were not found to be linearly correlated showing R2factor less than 0.0012. Notably CK and myoglobin levels, when plotted throughregression, were leading with exceptional correlation, with R2 0.491 for totalpatients, R2 0.512 for males and 0.532 for females.It was suggested that by combining both CK and myoglobin estimation inpatients with myopathies especially dermatomyositis or polymyositis, it providesbetter overall impression of muscle damage and related conditions.Correlation of CK and Mb levels in myopathies.