Comparative analysis of residual neurovirulence of vaccine and low attenuated rubella virus (Matonaviridae: Rubivirus: Rubella virus) strains in the experiments on the macaque rhesus (Macaca mulatta) monkeys | Zendy

O. A. Shamsutdinova | Zendy; Dmitry Bulgin | Zendy; Д. Д. Карал-оглы | Zendy; I. N. Lavrentieva | Zendy; Игорь Наумович Клоц | Zendy

Open Access

Comparative analysis of residual neurovirulence of vaccine and low attenuated rubella virus (Matonaviridae: Rubivirus: Rubella virus) strains in the experiments on the macaque rhesus (Macaca mulatta) monkeys

Author(s) -

O. A. Shamsutdinova,

Dmitry Bulgin,

Д. Д. Карал-оглы,

I. N. Lavrentieva,

Игорь Наумович Клоц

Publication year - 2022

Publication title -

problems of virology

Language(s) - English

Resource type - Journals

eISSN - 2411-2097

pISSN - 0507-4088

DOI - 10.36233/0507-4088-97

Subject(s) - virology , rubella , macaque , rubella virus , rubella vaccine , biology , virus , attenuated vaccine , togaviridae , rhesus macaque , vaccination , immunology , medicine , virulence , measles , paleontology , biochemistry , gene

Rubella is currently an infection controlled by specific prophylaxis. Not only the right vaccine prophylaxis strategy and tactics, but also the use of effective and safe vaccine preparations is crucial for the elimination of this disease.The aim of the investigation was to study the morphological and pathogenetic patterns of changes developing in the central nervous system (CNS) and internal organs of monkeys (Haplorhini) during intracerebral inoculation with 2 strains of rubella virus (Matonaviridae: Rubivirus: Rubella virus) (RV): highly attenuated Orlov-B, and low attenuated Orlov-14.

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