Open AccessComparative analysis of residual neurovirulence of vaccine and low attenuated rubella virus (Matonaviridae: Rubivirus: Rubella virus) strains in the experiments on the macaque rhesus (Macaca mulatta) monkeys
Author(s) -
О. А. Шамсутдинова,
Dmitry Bulgin,
Д. Д. Карал-оглы,
И. Н. Лаврентьева,
I N Klots
Publication year - 2022
Publication title -
voprosy virusologii
Language(s) - English
Resource type - Journals
eISSN - 2411-2097
pISSN - 0507-4088
DOI - 10.36233/0507-4088-97
Subject(s) - virology , rubella , macaque , rubella virus , rubella vaccine , biology , virus , attenuated vaccine , togaviridae , rhesus macaque , vaccination , immunology , medicine , virulence , measles , paleontology , biochemistry , gene
Rubella is currently an infection controlled by specific prophylaxis. Not only the right vaccine prophylaxis strategy and tactics, but also the use of effective and safe vaccine preparations is crucial for the elimination of this disease.The aim of the investigation was to study the morphological and pathogenetic patterns of changes developing in the central nervous system (CNS) and internal organs of monkeys (Haplorhini) during intracerebral inoculation with 2 strains of rubella virus (Matonaviridae: Rubivirus: Rubella virus) (RV): highly attenuated Orlov-B, and low attenuated Orlov-14.